EPO Isoform Analysis
Easy-to-use isoform analysis tool for distinguishing between various endogenous and recombinant human erythropoietins and erythropoietin analogues affinity purified from urine, serum or plasma.
EPO WGA MAIIA Isoform Distribution Kit (Art. No. 1310)
Using a rapid dip-stick procedure the total amount of EPO in the sample is measured, and also a certain proportion of EPO. This proportion will vary depending on how strongly the EPO isoforms contained in the sample interact with wheat germ agglutinin
(WGA) lectin ligands on the dip-stick. Measuring the proportion makes it possible to spot differences in the EPO isoform pattern between samples.
Differences in the EPO isoform pattern may occur between EPO produced in different cell types, such as liver or kidney cells, between normal cells and tumor cells, or between human cells and cells from other species, such as many recombinant EPO variants. Differences in the isoform pattern of proteins may affect their biological function.